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Attentional abnormalities in autism: an electrophysiological study of the basal forebrain and central nucleus of the amygdala.

La Jolla
State/Province Full: 
United States

One prominent alteration in autistics lies in attentional processing. People with autism show specific deficits in some attentional tasks and better than normal performance in others. Attentional processing is carried out in the brain in large part by the basal forebrain cholinergic system. This system is also modulated by the amygdala. Both the basal forebrain and the amygdala have been shown to be atypical in autistic brains, with the central nucleus of the amygdala (CN) containing unusually small, densely packed neurons, and the substantia inominata/nucleus basalis (SI/nBM) region of the basal forebrain containing exceedingly high levels of BDNF, a neurotrophic factor that is implicated in neuronal excitability. The aim of this project is to use an animal model to determine whether these known abnormalities of autistic brains can themselves mediate the atypical attentional patterns of behavior seen in autism. Neural recordings will be obtained in the SI/nBM and CN of rats during attentional tasks comparable to those impaired in autistics, and that have been shown to be dependent upon function of the basal forebrain cholinergic system. Neural activity and behavior will be monitored after partial lesions of the CN, and after infusion of high levels of BDNF into the SI/nBM. What this means for people with autism: By characterizing alterations in neuronal function arising from dysfunction in this system, it may be possible to define target sites for therapeutic intervention to aid attentional processing in individuals with autism.