Defiance College's ASD Affinity Program accepts academically-qualified college applicants who might require help in navigating the traditional college residential campus. Varying levels of academic, social, and residential support assist students in personal growth and in meeting their professional goals.

The program fosters independence for young adults with autism by providing a residential campus experience with numerous services in place to maximize opportunities for success and entry into the workforce. Participating students receive campus housing with support from trained resident advisors and peer interventionists.

The ASD Affinity Program builds on Defiance College's success with its Hench Autism Studies Program, in which high school students with autism receive high school-level instruction on the DC campus in coordination with Defiance City Schools.