Autism Speaks at Neuroscience 2013

Date: 
November 09, 2013
Autism Speaks researchers participate in world’s largest conference on brain development; more than 200 presentations on autism studies

Neuroscience 2013, the world’s largest research conference on brain development and function, convened in San Diego today, with more than 30,000 attendees. As the annual meeting of the Society for Neuroscience (SfN), this year’s conference will include more than 200 presentations on autism-related research.

These presentations will feature the early findings of ongoing research projects before the studies appear in peer-reviewed journals. As such Neuroscience 2013 plays a special role in fostering discussion of emerging discoveries and new directions in research. It is also a vitally important opportunity for fruitful discussions between scientists with different areas of expertise.

"When it comes to understanding the mysteries of the brain, SfN is the most important research conference in the world today," says Autism Speaks Chief Science Officer Rob Ring. "Breakthroughs being reported at SfN this week offer a preview to the innovations in brain health of tomorrow."

For our daily coverage of autism news from Neuroscience 2013, click here

The table below lists Autism Speaks-funded senior scientists and research fellows presenting early findings from their Autism Speaks research projects. Follow the hyperlinks to read the scientific abstracts of their SfN presentations and descriptions of their related Autism Speaks research grants.

You can also join a Twitter Q&A with autism scientists attending the conference on Tuesday, Nov. 12 at 12 pm Pacific/3 pm Eastern. Featured experts will include Autism Speaks Senior Director of Discovery Neuroscience Dan Smith and Autism Speaks Senior Director for Environmental and Clinical Sciences Alycia Halladay. To participate, follow the hashtag #SFNautism.

Researchers & Institutions

Neuroscience 2013 presentations

Autism Speaks research grant

*J. L. SILVERMAN1, P. T. GASTRELL2, M. C. PRIDE1, J. E. HAYES1, M. SOLOMON1, J. N. CRAWLEY1,21UC Davis Sch. of Med., Sacramento, CA; 2Lab. of Behavioral Neurosci., Natl. Inst. of Mental Hlth., Bethesda, MD

Touchscreen learning of transitive inference in B6 mice and the BTBR mouse model of autism

Human Biomarkers of Autism

Preclinical Autism Consortium for Therapeutics

*M. YANG1, D. LOUREIRO2, D. KALIKHMAN2, J. N. CRAWLEY1,21MIND Inst. and Dept. of Psychiatry. UC Davis, Sacramento, CA; 2Lab. of Behavioral Neurosci., Natl. Inst. of Mental Hlth. Intramural Res. Program, Bethesda, MD

Where did she go? Male mice emit distinct ultrasonic vocalizations when the female is removed from the social interaction environment

Human Biomarkers of Autism

Preclinical Autism Consortium for Therapeutics

*M. NEBEL1,2, A. ELOYAN3, C. NETTLES2, K. SWEENEY2, A. CHOE1, A. BARBER1,2, B. CAFFO3, J. PEKAR1,2, S. MOSTOFSKY1,21Johns Hopkins Sch. of Med., Baltimore, MD;2Kennedy Krieger Inst., Baltimore, MD; 3Johns Hopkins Bloomberg Sch. of Publ. Hlth., Baltimore, MD

Visuomotor connectivity relates to symptom severity in children with autism

049.Human Biomarkers of Autism

Understanding the Brain Basis of Impaired Imitation Learning in Autism

Meixner Postdoctoral Fellow

*K. A. MCEVOY1,3, S. JESTE2,31Ctr. for Autism Res. & Treatment, UCLA, LOS ANGELES, CA; 2UCLA, Los Angeles, CA; 3Ctr. for Autism Res. & Treatment, University of California, Los Angeles, CA

Methodological considerations for processing quantitative EEG data in children with and without a developmental disability

049.Human Biomarkers of Autism

Electrophysiologic Biomarkers of Language Function in Autism Spectrum Disorders

Weatherstone Predoctoral Fellow

*J. L. STEIN1, J. S. GRIMLEY2, V. MENON2, D. H. GESCHWIND1, A. KAYKAS21Neurol., UCLA, Los Angeles, CA; 2Allen Inst. for Brain Sci., Seattle, WA

TALENSeek: A validated program for identifying genomic engineering sites

101.Bioinformatics

Genetic models of autism in human neural progenitor cells: a platform for therapeutic discovery

Meixner Postdoctoral Fellow

*Z. YAN, W.-L. WU, E. Y. HSIAO, P. H. PATTERSON; Div. of Biol., Caltech, Pasadena, CA

Maternal infection perturbs fetal brain development through IL-6 signaling

244.Developmental Disorders Associated with Prenatal Events

How Does IL-6 Mediate the Development of Autism-Related Behaviors? and Role of Cytokines in Mediating the Effects of Maternal Immune Activation on the Fetal Brain

Weatherstone Predoctoral Fellow

*H. BELINSON1, J. NAKATANI1, R. Y. BIRNBAUM2, M. BERSHTEYN1, B. BABINEAU1, R. J. MCEVILLY3, J. LONG1, K. WILLERT4, N. AHITUV2, M. G. ROSENFELD3, A. WYNSHAW-BORIS1,51Pediatrics, 2Dept. of Bioengineering and Therapeut. Sci., Inst. For Human Genetics, UCSF, San Francisco, CA; 3Dept. and Sch. of Med., Howard Hughes Med. Institute, UCSD, San Diego, CA; 4Deparment of Cell and Mol. Biol., Inst. for Regenerative Medicine, UCSD, San Diego, CA; 5Dept. of Genet. and Genome Sci., Case Western Reserve Univ. Sch. of Med., Cleveland, OH

β-catenin transcriptionally regulates Brn2 and control early brain overgrowth

244.Developmental Disorders Associated with Prenatal Events

Pathologic and Genetic Characterization of Novel Brain Cortical Patches in Young Autistic Brains
 

Meixner Postdoctoral Fellow

*S. H. MOSTOFSKY1,3, M. NEBEL1, L. JACOBSON1, J. WEXLER4, B. S. CAFFO5, J. J. PEKAR2,3, A. D. BARBER2,31Neurology/Developmental Cognitive Neurol., 2Kennedy Krieger Institute, Johns Hopkins Univ. Sch. o, Baltimore, MD; 3Johns Hopkins Sch. of Med., Baltimore, MD; 4Kennedy Krieger Inst., Baltimore, MD; 5Johns Hopkins Sch. of Publ. Hlth., Baltimore, MD

Altered connectivity in default mode and cingulo-opercular networks in children with ADHD

246.Attention Deficit Hyperactivity Disorder: Child Development

Understanding the Brain Basis of Impaired Imitation Learning in Autism

Meixner Postdoctoral Fellow

*L. DE LA TORRE-UBIETA, J. L. STEIN, N. N. PARIKSHAK, D. LU, J. K. LOWE, E. WEXLER, D. H. GESCHWIND; UCLA, Los Angeles, CA

In vitro modeling of brain development using human neural stem cells extensively parallels In vivo development

500.Neural Differentiation and Disease Modeling Using Stem Cells or Reprogramming

Genetic models of autism in human neural progenitor cells: a platform for therapeutic discovery

Meixner Postdoctoral Fellow

*T. C. JARAMILLO, H. E. SPEED, J. REIMERS, Z. XUAN, S. LIU, C. M. POWELL; Neurol. & Neurotherapeutics, UT Southwestern Med. Ctr., Dallas, TX

Altered synaptic plasticity and abnormal behaviors in Shank3 exon 4-9 mutant mouse model of autism

531.Neural Mechanisms Associated with Autistic Behaviors in Animals

Preclinical therapeutic target validation of glutamate receptors in Shank3 models of autism, Animal Models of Autism: Pathogenesis and Treatment

Meixner Postdoctoral Fellow

*J. M. YAU1, M. B. NEBEL3, J. HUA2, J. E. DESMOND11Neurol., Johns Hopkins Univ., BALTIMORE, MD; 2Russell H. Morgan Dept. of Radiology and Radiological Sci., Johns Hopkins Univ., Baltimore, MD; 3Kennedy Krieger Inst., Baltimore, MD

Direct comparison of network connectivity revealed by resting-state fMRI and concurrent TMS-fMRI

550.Mutisensory: Cross-Modal Processing in Humans

Understanding the Brain Basis of Impaired Imitation Learning in Autism

Meixner Postdoctoral Fellow

*J. R. COHEN1, A. D. BARBER2, M. B. NEBEL2, M. D'ESPOSITO1, S. H. MOSTOFSKY21Helen Wills Neurosci. Inst., UC Berkeley, Berkeley, CA; 2Kennedy Krieger Inst., Baltimore, MD

Global brain organization is disrupted in children with ADHD

573.Working Memory and Executive Function III

Understanding the Brain Basis of Impaired Imitation Learning in Autism

Meixner Postdoctoral Fellow

*M. ESTES, A. MCALLISTER; UC Davis, Davis, CA

IL-1 beta alters cortical connectivity in development and disease through regulating synaptic localization of IL-1 beta receptors

596.Synapse Formation: Transsynaptic Mechanisms

Gene-environment interactions regulating synapse density and function in ASD

Weatherstone Predoctoral Fellow

*M. KOUSER1, H. E. SPEED1, J. M. REIMERS1, C. M. DEWEY1, A. J. WIDMAN1, S. LIU1, T. C. JARAMILLO1, P. F. WORLEY2, C. M. POWELL11Neurol. and Neurotherapeutics, UTSouthwestern, Dallas, TX; 2Neurosci., John Hopkins Univ. Sch. of Med., Baltimore, MD

Behavioral characterization of Shank3 homer binding domain deletion model of autism

692.Genetic Correlates of Autism

Temporally Controlled Genetic Rescue of Shank3 Autism Model, Animal Models of Autism: Pathogenesis and Treatment and Shank3 mutant characterization in vivo.

 

*W.-L. WU, P. H. PATTERSON; Div. of Biol., Caltech, Pasadena, CA

The interaction between α7nAChR and maternal infection in regulating schizophrenia- and autism-like behaviors

718.Genetic Correlates of Autism

The Mechanism of the Maternal Infection Risk Factor for Autism and Role of Cytokines in Mediating the Effects of Maternal Immune Activation on the Fetal Brain

*N. GUPTA1, M. KOUSER1, P. WORLEY2, C. POWELL11Univ. of Texas At Southwestern, Dallas, TX; 2Johns Hopkins Univ., Baltimore, MD

Characterization of neuronal morphology in a shank3 exon 21 deletion mouse model of autism

718.Genetic Correlates of Autism

Temporally Controlled Genetic Rescue of Shank3 Autism Model, Animal Models of Autism: Pathogenesis and Treatment, and Shank3 mutant characterization in vivo.

 

*F. ESPINOSA, J. M. REIMERS, C. F. OCHOA, C. M. DEWEY, C. M. POWELL; Neurol. and Neurotherapeutics, U.T. Southwestern Med. Ctr., Dallas, TX

Neuroligin-1 deficient mice exhibit pathway-specific alterations in striatal NMDA receptor-mediated currents

719.Genetic Models of Autism in Animals

Animal Models of Autism: Pathogenesis and Treatment, The Role of Neuroligins in Cognitive Function: Implications for Autism

*B. A. BABINEAU1, J. NAKATANI1,2, H. BELINSON1, A. WYNSHAW-BORIS1,31Dept. of Pediatrics and Inst. of Human Genet., Univ. of California San Francisco, San Francisco, CA; 2Biomed. Resonance Sci. Ctr., Shiga Univ. of Med. Sci., Seta-Tsukinowa, Otsu, Shiga, Japan; 3Dept. of Genet. and Genome Sci., Case Western Reserve Univ., Cleveland, OH

Sociability and amygdala-dependent memory deficits in Dishevelled mutant mice

719.Genetic Models of Autism in Animals

Pathologic and Genetic Characterization of Novel Brain Cortical Patches in Young Autistic Brains
 

Meixner Postdoctoral Fellow

*A. ABBOTT1,2, C. L. KEOWN1,2, A. NAIR1,2,3, G. KOOR1,2, S. KIRTLAND1,4, D. GOBLE1,4, R.-A. MÃœLLER1,21San Diego State Univ., San Diego, CA; 2Brain Develop. Imaging Lab., San Diego, CA; 3UCSD, La Jolla, CA; 4Biomechanics Lab., San Diego, CA

Impaired functional connectivity in networks underlying balance in Autism Spectrum Disorder

809.Brain Imaging and Tissue Markers in Autism

Thalamocortical Connectivity in Children and Adolescents with ASD-A Combined fcMRI and DTI approach

Weatherstone Predoctoral Fellow

*A. T. KNOLL1, S. CHOI1, B. REEB-SUTHERLAND2, N. A. FOX3, P. LEVITT11Cell and Neurobio., USC, Los Angeles, CA; 2Psychology, Florida Intl. Univ., Miami, FL;3Human Develop. and Quantitative Methodology, Univ. of Maryland, College Park, MD

Heterogeneity in social behavior and relation to associative learning in BXD recombinant inbred mice

866.Neural Mechanisms for Social Behavior across Evolutionary Phylogeny

Factors influencing early associative learning as a precursor to social behavior heterogeneity

Meixner Postdoctoral Fellow