The Autism Genetic Resource Exchange (AGRE) has reached a significant milestone this month, having collected its 10,000th DNA sample from families with autism spectrum disorders (ASD). AGRE represents the world's largest private repository of clinical and genetic information for families affected with an ASD. The collection has grown to include over 2,000 families, the majority having 2 or more affected children. AGRE is funded by Autism Speaks and the National Institute of Mental Health (NIMH) to support the data collection efforts of the program, and over the last 13 years, this resource has significantly accelerated progress in autism research. AGRE's biomaterials repository, which includes DNA, plasma, serum, and cell lines, has now grown to exceed 10,000 samples, offering researchers an unprecedented resource for their scientific studies. The community of AGRE-approved researchers has grown to include 240 scientists worldwide and over the last decade, the resource has generated over 160 research papers, 52 papers in the last 2 years alone. We want to thank all of the families who continue to support the AGRE program and who remain committed to our mission. Together we will help solve the puzzle.