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Relation of Sleep Epileptiform Discharges to Insomnia and Daytime Behavior

City: 
Nashville
State/Province: 
TN
State/Province Full: 
Tennessee
Country: 
United States

Children with autism spectrum disorders (ASD) are known to have a higher prevalence of epilepsy and sleep disturbances which may affect daytime functioning. Interictal epileptiform discharges (IEDs) are patterns of abnormal brain activity associated with epilepsy which have also been found to be prevalent in people with ASDs. Whether IEDs are involved in sleep disturbance in children with ASD is unknown, and this proposed study is aimed at examining potential links between IEDs, sleep, and behavior. Researchers will test the hypothesis that IEDs during sleep may affect sleep patterns, contributing to the underlying sleep disturbance which may in turn result in behavioral problems. Dr. Barnes and colleagues will examine the prevalence of IEDs during sleep in a cohort of children with ASD. IEDs are measured by EEGs, which record electrical activity in the brain in a noninvasive manner. EEG and behavioral data will be used to examine the relationships between sleep IEDs, sleep disturbances, and daytime behavior in these children. If IEDs are found to disrupt sleep and contribute to difficulties with daytime behavior, then it is possible that drugs that suppress epileptiform discharges could be beneficial in treating behavioral problems in some children with ASDs.