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Metabotropic Glutamate Receptor 7: A Novel Therapeutic Target for Rett Syndrome

City: 
Nashville
State/Province: 
TN
State/Province Full: 
Tennessee
Country: 
United States

Rett Syndrome is a devastating genetic disorder that affects 1:10,000 girls worldwide and is characterized by autism-like symptoms, loss of language skills, seizures, stereotyped behaviors, motor deficits, and cognitive impairments. Even though the cause of this disorder has been known for several years, very few pharmacological therapies have been developed and currently patients with this disease have few therapeutic options. The goals of these studies are to investigate the therapeutic potential of activation of metabotropic glutamate receptors in Rett Syndrome and to gain a better understanding of how these receptors play a role in the pathophysiology of disease; both of which could increase therapeutic options and quality of life for patients with Rett Syndrome.