Developmental Outcomes in Later-Born Siblings of Children with ASD

Completed

Ozonoff, Sally

University of California, Davis

$24,225.00

1 year

Other

Davis

CA

United States

2008

http://www.ucdavis.edu

City: 
Davis
State/Province: 
CA
State/Province Full: 
California
Country: 
United States

One of the central goals of research investigating infant siblings of probands with ASD is to understand the range of outcomes they experience (e.g., ASDs, speech and language delays, other developmental conditions). Infant and family factors may influence the range of developmental outcomes. At present, the best data about developmental outcomes of later born siblings is derived from family genetic studies, most of which were conducted in the 1980s and early 1990s. However, given recent shifts in the epidemiology of autism and related ASDs, these relative risk figures may have changed significantly. It is important to examine how specific risk factors, including proband and infant sibling sex, number of affected family members, and functioning level of the proband, influence the range of developmental outcomes in the infant siblings. To achieve these goals, the BSRC will be combining data on 1100 high risk siblings and 400 low risk controls from 22 sites. Combining data will greatly increase statistical power and the reliability of estimation. Indeed, it is unlikely that any one site alone will have the statistical power to address these questions. This project will: examine rates of ASD and broader developmental outcomes in infant siblings of probands with ASD and 2) identify factors that may influence the range of developmental outcomes among infant siblings of probands with ASD and, when appropriate, examine the influences of the same factors in the comparison sample. [BSRC]