Biology

Dissecting the 16p11.2 CNV endophenotype in induced pluripotent stem cells

Autism spectrum disorders (ASDs) are a heterogeneous group of disorders characterized by language impairment, deficits in social interactions and communication as well as stereotyped behaviors and restricted interests. Chromosomal abnormalities su... More...

Neural Synchrony and Plasticity in Children with Autism

Disrupted brain communication in autism spectrum disorder (ASD) is supported by an extensive literature of neuroimaging findings, as reflected in disrupted white matter microstructure and functional connectivity analyses (synchronization of activa... More...

Neural Basis of Response to Virtual Reality Social Cognition Training in Adults with ASD

Virtual Reality-Social Cognition Training (VR-SCT) is a behavioral training program designed to improve social communication skills in young adults with ASD and has been empirically validated to be effective with behavioral evidence. In this proje... More...

Discovery and Functional Characterization of Gene Regulatory Networks (GRNs) of Autism Risk Genes

A complex genetic architecture that underlies risk for autism spectrum disorders (ASD) has emerged. This complexity is reflected in two general principles: i) gene misregulation underlies a wide range of human disease; ii) there is enrichment of c... More...

EEG biomarkers of language and literacy abilities in minimally verbal children with ASD

Approximately 30% of children with ASD are minimally verbal past age 5. There is limited information about their understanding of spoken or written language despite anecdotal reports of great heterogeneity in these domains. There are few appropria... More...

Autism Spectrum Disorders: Genomes to Outcomes

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition associated with lifelong disabilities which has become one of today's most urgent public health challenges as it affects more than 1% of the population. The demand for support servic... More...

Jones Lab Collaboration with the Autism Speaks (PACT)

This project represents the addition of a new site to the Preclinical Autism Consortium for Therapeutics (PACT), a focused preclinical target selection and prosecution effort to de-risk the discovery and development of medicines aimed at treating ... More...

CIHR Chair: Autism Spectrum Disorders Treatment and Care Research

This project will study innovative approaches to expand treatment and care research to address mental health problems in Canadians with autism across the lifespan. They will examine why people with ASD are prone to develop mental health problems, ... More...

Histone Methylation Mapping in Autism

Epigenetics is the study of gene regulation and organization that occurs independent of changes in a gene’s “code,” or DNA sequence. Indeed, the vast majority of genes in a given cell remain off, or inactive, at a given time. As in other par... More...

Investigating the contribution of DNA methylation to autism phenotypes in disorders of 7q11.23

Williams Syndrome (WS) and 7q11.23 Duplication Syndrome (Dup7) are rare neurodevelopmental disorders caused by deletion and duplication respectively, of 26 genes on chromosome 7q11.23. Individuals with WS and Dup7 show a range of cognitive and beh... More...

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